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[Preprint]. 2023 Jul 1:2023.06.29.547069. [Version 2] doi: 10.1101/2023.06.29.547069

Figure 5: Enrichment of differential expression signals from local TrkB knockdown across snRNA-seq LS dataset.

Figure 5:

(A) Enrichment analysis of all, positive, and negative DEGs from the TrkB knockdown dataset across broad cellular clusters. (B) Enrichment analysis of all, positive, and negative DE genes from the TrkB knockdown dataset across all neuronal clusters from the septum. (C) Heatmap of DE genes from the TrkB knockdown dataset enriched in lateral septal and microglial broad clusters across broad clusters. DE genes from the TrkB knockdown dataset are divided into genes unique to the LS, plasticity genes, and neurodevelopmental genes. (D) Heatmap of DE genes from the TrkB knockdown dataset that are enriched in the lateral septal broad cluster across the neuronal clusters. Heatmaps show normalized expression values (logcounts) centered and scaled. Violin plots of (E) Ywhaz, (F) Sgip1, (G) Cnr1, (H) G3bp2, (I) Cpne7, (J) Atcay, (K) Zmat4, and (L) Nxph1 expression, genes with unique LS expression identified from downregulated DE genes from the TrkB knockdown dataset enriched in the LS broad cluster, in addition to Cnr1 expression.