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. 2023 Jul 7;22:207. doi: 10.1186/s12936-023-04632-0

Table 1.

Resistant k13 mutations detected by the optimized GATK4 at hexaploid and diploid modes versus GATK3

K13 mutations Optimized GATK4 (ploidy6) Optimized GATK4 (ploidy2) GATK3
A481V 5 5 5
C580Y 664 649 650
G449A 6 5 5
G538V 24 21 21
I543T 36 34 33
M446I 38 36 36
N458Y 17 17 17
P441L 28 28 28
P553L 24 23 23
P574L 30 30 30
R539T 65 63 62
R561H 24 24 24
Y493H 111 106 106

All the mutations were found in South-East Asia except for one sample carrying the C580Y allele that was collected in Cameroon