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. 2023 Jul 6;25:81. doi: 10.1186/s13058-023-01679-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Antitumor activity of DZD1516 in combination with T-DM1 or T-DXd in BT474C1-Luci Mono1 xenograft mice model. The BT474C1-Luci Mono1 cell model was a stable clone generated by transfection of luciferase gene into BT474 cell line and selection of stable clones. A Efficacy study of DZD1516 in combination with T-DM1 in the BM model. n = 9/group. ****P < 0.0001 (vs. T-DM1 group, two-way ANOVA). B Efficacy study of DZD1516 in combination with T-DM1 in the SC model. n = 10/group. ns: not significant (vs. T-DM1 group, two-way ANOVA). C Efficacy study of DZD1516 in combination with T-DXd in the BM model. ***P < 0.001 (vs. T-DXd group, two-way ANOVA). D Efficacy study of DZD1516 in combination with T-DXd in the SC xenograft model. BID: twice daily; q2w: once every 2 weeks. qw: once weekly. BM brain metastasis, SC subcutaneous