Table 1:
SNPs identified by DSILT to interact with the statin genetic variants rs17238484-G on the risk for T2D. The second column presents the name of the gene where the SNP locates. The third column presents the minor allele frequency (MAF) of each SNP averaged over the three sites. The last three columns respectively present the –values obtained using One–shot approach with all the studies, One–shot with solely the datasets and and the proposed method with all the studies. The –values shown in black fonts represent the SNPs selected by each method.
| SNP | Gene | MAF | One–shot | MVP–only | DSILT |
|---|---|---|---|---|---|
| rs12328675-T | COBLL1 | 0.13 | 1.1×10−3 | 2.3 × 10−3 | 6.0×10−4 |
| rs2200733-T | LOC729065 | 0.18 | 3.7 × 10−2 | 5.7 × 10−3 | 6.2×10−4 |
| rs581080-G | TTC39B | 0.22 | 3.6×10−6 | 1.1×10−6 | 2.6×10−6 |
| rs35011184-A | TCF7L2 | 0.22 | 1.9 × 10−2 | 5.2 × 10−2 | 8.6×10−4 |
| rs838880-T | SCARB1 | 0.36 | 6.7×10−4 | 6.0×10−5 | 6.2×10−4 |