Table 1.
Table of regulatory pathways.
| Naïve | Activated | SLECs | TCM | TRM | ||
|---|---|---|---|---|---|---|
| Cellular Processes | TGFβ | Activation (ref 24) |
Proliferation (ref 11) | Proliferation (ref 11) |
Cell Survival (ref 87) | Development, Maintenance (ref 149) |
| Apoptotic cell death (ref 82) | ||||||
| Smad4 | Differentiation (ref 10,11) |
Differentiation (ref 10, 11) |
Differentiation (ref 9, 11) | |||
| Regulated genes | TGFβ | Itgae (CD103) (ref 14) |
Bcl2 (ref 82) | Bcl2 (ref 87) | Itgae (CD103) (ref 23, 149) |
|
| Zeb1 (ref 148) | Zeb1 (ref 148) | |||||
| Zeb2 (ref 148) | Zeb2 (ref 148) | |||||
| KLRG1 (ref 120) | Granzyme B (ref 87) |
T-bet (ref 87) |
T-bet (ref 146) | |||
| VISTA (ref 30) | CXCR3 (ref 101) | Eomes (ref 87) |
Eomes (ref 146) |
|||
| PSGL-1 (33)* | Foxo1, Bcl6 (ref 87) |
S1PR5, KLF2 (refs 113, 114) |
||||
| Smad4 | Itgae (CD103) (ref 9) |
KLRG1 (ref 11) |
Sell (CD62L) (ref 11) |
Itgae (CD103) (ref 9) |
||
| CX3CR1 (ref 9) |
Eomes (ref 9) |
Hobit (ref 9) |
||||
*Only confirmed in CD4 T cells.
White boxes indicate positive regulation by TGFβ. Grey boxes indicate negative regulation by TGFβ.