Table 3.
Baseline and cumulative variables associated with the occurrence of radiographic progression
| Variable | Uni-variable (not adjusted) | Model 1* (uni-variable) | Model 2† (multi-variable) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p-value | Odds ratio | 95% CI | p-value | Odds ratio | 95% CI | p-value | |||
| Baseline mTSS | 1.024 | 1.007~1.041 | 0.022 | 1.036 | 1.011~1.062 | 0.004 | 1.036 | 1.010~1.063 | 0.006 | ||
| Cumulative RF (IU/mL) | 1.000 | 1.000~1.000 | 0.854 | 1.000 | 1.000~1.000 | 0.102 | |||||
| Cumulative ESR (mm/h) | 1.003 | 1.000~1.006 | 0.134 | 1.004 | 1.001~1.007 | 0.013 | 1.001 | 0.993~1.008 | 0.887 | ||
| Cumulative CRP (mg/dL) | 1.021 | 0.990~1.053 | 0.134 | 1.024 | 0.993~1.057 | 0.133 | |||||
| Cumulative TJC | 1.020 | 1.001~1.040 | 0.037 | 1.026 | 1.004~1.048 | 0.021 | 0.978 | 0.936~1.014 | 0.384 | ||
| Cumulative SJC | 1.090 | 1.029~1.155 | 0.001 | 1.099 | 1.034~1.167 | 0.002 | 1.099 | 1.019~1.185 | 0.014 | ||
| Cumulative DAS28-ESR | 1.053 | 1.013~1.095 | 0.029 | 1.060 | 1.018~1.103 | 0.005 | 1.017 | 0.894~1.156 | 0.802 | ||
| Cumulative sCD14 (pg/mL) | 1.000 | 1.000~1.000 | 0.148 | 1.000 | 1.000~1.000 | 0.245 | |||||
CI: confidence interval, mTSS: modified total Sharp score, RF: rheumatoid factor, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, TJC: tender joint count, SJC: swollen joint count, DAS28: disease activity score 28, sCD14: soluble CD14. *Model 1: adjusted for age, sex, and disease duration. †Model 2: clinical variables with p-values < 0.1 in ‘Model 1’ were included in multi-variable analysis with adjustment for age, sex, and disease duration.