Figure 3.

The percentage of participants achieving ≥ 5%, ≥ 10%, ≥ 15%, and ≥ 20% weight loss for each medication. Data were extracted from the following trials: XENical in the Prevention of Diabetes in Obese Subjects (XENDOS; orlistat),⁸ Contrave Obesity Research I (COR-I; naltrexone/bupropion [NB] extended-release [ER]),²³ Satiety and Clinical Adiposity-Liraglutide (SCALE) Obesity and Prediabetes and its extension (liraglutide 3.0 mg),^37,40 EQUIP (phentermine/topiramate [P/T] ER 1 year),⁴⁹ SEQUEL (P/T ER 2 years),³¹ Semaglutide Treatment Effect in People with obesity (STEP) 1 (semaglutide 2.4 mg),¹³ and SURMOUNT-1 (tirzepatide 15 mg).⁴⁸