Table 5.
Top tox functions modified with Covid-19 infection during pregnancy.
| Modified Tox Functions | Category | Range of P-values for genes involved | Number of Molecules |
|---|---|---|---|
| Cardiac Arteriopathy | Cardiotoxicity | 6.61E-03-2.97E-01 | 4 |
| Cardiac Stenosis | 8.26E-02-8.26E-02 | 1 | |
| Congenital Heart Anomaly | 1.01E-01-4.07E-01 | 2 | |
| Liver Hyperplasia/Hyperproliferation | Hepatotoxicity | 2.65E-04-5.5E-01 | 74 |
| Liver Hyperbilirubinemia | 1.97E-02-1.97E-02 | 1 | |
| Liver Proliferation | 8.87E-02-8.87E-02 | 1 | |
| Liver Inflammation/Hepatitis | 2.2E-01-4.35E-01 | 2 | |
| Liver Cirrhosis | 2.43E-01-5.28E-01 | 3 | |
| Liver Fibrosis | 2.43E-01-5.28E-01 | 3 | |
| Liver Cholestasis | 3.33E-01-3.33E-01 | 1 | |
| Nephrosis | Nephrotoxicity | 6.61E-03-6.61E-03 | 1 |
| Renal Dysplasia | 6.61E-03-7.62E-03 | 2 | |
| Renal Hypoplasia | 6.61E-03-6.61E-03 | 1 | |
| Renal Necrosis/Cell Death | 3.3E-02-5.41E-01 | 7 | |
| Renal Proliferation | 1.44E-01-1.44E-01 | 3 | |
| Glomerular Injury | 2.23E-01-5.44E-01 | 2 | |
| Renal Inflammation | 2.23E-01-5.44E-01 | 2 | |
| Renal Nephritis | 2.23E-01-5.44E-01 | 2 |