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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Nature. 2022 Nov 30;613(7945):767–774. doi: 10.1038/s41586-022-05588-y

Extended Data Fig. 4 |. Comparison of bitopic structures to BU72 structure.

Extended Data Fig. 4 |

A, C, Side chains of μOR orthosteric pocket residues are shown for the C5-guano (A) and C6-guano (C) bound μOR–Gi complex (green) in comparison with the BU72 bound μOR (PDB code 5C1M; pink). The orthosteric pocket residues of μOR in complex with bitopic ligands and BU72 show nearly identical conformations. B, D, Side chains of μOR site-2 and Na+ site residues are shown for the C5 guano (B) and C6 guano (D) bound μOR–Gi complex (green) in comparison with the BU72 bound μOR (PDB code 5C1M; pink). The site-2 and Na+ site residues of μOR in complex with bitopic ligands and BU72 show nearly identical conformations.