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. 2023 Mar 3;18(10):2301–2306. doi: 10.4103/1673-5374.369121

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Protective effect of umbilical cord-derived MSC-EV treatment on retina damage and ganglion cell loss induced by COH.

(A, B) HE (A) and RBPMS (B) staining of the retina after COH and treatment with MSC-EVs. MSC-EV treatment reversed the structural changes and retinal ganglion cell loss induced by COH. The RBPMS⁺ cells were stained red (by Alexa Fluor 594, green arrows). Scale bars: 25 μm. (C) Number of RBPMS⁺ cells. Data are expressed as the mean ± SD (n = 4/group). **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by Tukey’s post hoc tests). COH: Chronic ocular hypertension; EV: extracellular vesicle; GCL: ganglion cell layer; HE: hematoxylin and eosin; INL: inner nuclear layer; IPL: inner plexiform layer; MSC: mesenchymal stem cell; ONL: outer nuclear layer; OPL: outer plexiform layer; PR (IS/OS): photoreceptor (inner segment/outer segment); RBPMS: RNA-binding protein with multiple splicing.