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. 2023 Jan 30;18(10):2291–2300. doi: 10.4103/1673-5374.368300

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Microglia pyroptosis and the therapeutic mechanism of hucMSC-Exos in PD.

Stimulation of TLR4 with LPS activates the intracellular PI3K/Akt pathway, which then activates NF-κB and mTOR, accelerating NLRP3 inflammatory corpuscle aggregation and pyroptosis. hucMSC-Exos may inhibit pyroptosis through the TLR4/NF-κB and PI3K/AKT pathway. hucMSCs-Exos: Human umbilical cord mesenchymal stem cells-exosomes; LPS: Lipopolysaccharide; mTOR: mechanistic target of rapamycin; NLRP3: NOD-like receptor thermal protein domain associated protein 3; PD: Parkinson’s disease; TLR4: Toll-like receptor 4.