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RhoA regulates outer hair cells electromotility.
RhoA activates the Rho-related protein kinase (ROCK)/LIM kinases (LIMK) pathway to phosphorylate cofilin and the Rho-related protein kinase (ROCK)/protein kinase C-related kinase a (PKCa) pathway to phosphorylate adducin, thereby disrupting the cortical actin cytoskeleton, and altering the length of F-actin and the outer hair cytoskeleton. Both pathways antagonize each other, thereby regulating the electromotility of outer hair cells.
