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. 2023 Mar 3;18(10):2119–2126. doi: 10.4103/1673-5374.369100

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Copyright: © 2023 Neural Regeneration Research

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The cortical lamination structure of human embryonic cortex and hCOs.

(A) The human embryonic cortex is composed of a ventricular zone (VZ), subventricular zone (SVZ), intermediate zone (IZ), subplate zone (SP), cortical plate (CP) and marginal zone (MZ) with specific cortical cells at around 20 weeks of gestation. (B) HCOs spontaneously organize into similar cortical layers defined as the VZ, SVZ, CP, and MZ. (C) Missing non-ectoderm derived cell types in hCOs are being complemented in diverse ways. hCOs: Human cortical organoids; IP: intermediate progenitor cell; RG: radial glial cell; ORG: outer radial glial cell; OPC: oligodendrocyte progenitor cell.