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. 2023 Jul 7;18(7):e0281848. doi: 10.1371/journal.pone.0281848

Table 1. Distribution of minimum inhibitory concentrations (mg/L) for Escherichia coli isolates (n = 296) from faeces of Australian layer chickens.

The percentage of resistance based on ECOFF breakpoints (non-wild type) and clinical breakpoints (clinical resistance) are presented on the right-hand side (Percentage results were rounded to one decimal place). Vertical bars indicate position of ECOFF breakpoint.

Minimum Inhibitory Concentration (μg/ml)
drug 0.016 0.03 0.06 0.13 0.25 0.5 1 2 4 8 16 32 64 128 256 nw* nw_ci^ cr# cr_ci^
Amoxicillin-Clavulanate 2.4 8.4 39.2 40.9 6.4 2.7 9.1 6.1,13 2.7 1.2,5.3
Ampicillin .7 10.5 54.1 18.6 3.7 3 9.5 16.2 12.2,20.9 12.5 9,16.8
Cefoxitin 3.4 43.9 40.2 11.1 1.4 0 0,1.2 0.0 0,1.2
Ceftiofur 20.3 60.1 18.6 1 0 0,1.2 0.0 0,1.2
Ceftriaxone 95.9 3.7 .3 . . 0.0 0,1.2
Chloramphenicol 1 24.3 67.9 6.8 0 0,1.2 0.0 0,1.2
Ciprofloxacin 97 .3 1.4 1.4 2.7 1.2,5.3 0.0 0,1.2
Colistin 5.4 80.1 13.5 1 0 0,1.2 0.0 0,1.2
Florfenicol 4.4 49.7 43.6 2.4 2.4 1,4.8 45.9 40.2,51.8
Gentamicin 36.5 44.3 13.9 4.4 .7 .3 1 .2,2.9 0.3 0,1.9
Streptomycin 33.8 50.3 9.8 1.4 1.4 2 1.4 4.7 2.6,7.8 . .
Tetracycline 59.8 2.4 2 2 33.8 37.8 32.3,43.6 37.8 32.3,43.6
Trimethoprim/Sulfamethoxazole 87.8 1.7 1 .3 9.1 9.5 6.4,13.4 9.1 6.1,13

*nw—percent non-wildtype based on ECOFF breakpoints,

#cr—percent clinically resistant based on CLSI guidelines,

^ci—95% confidence interval.

Grey shading represents the concentration range tested. Values outside of the shaded area indicate isolate growth at all concentrations tested.