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. 2023 Jun 23;14:1173779. doi: 10.3389/fneur.2023.1173779

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Copyright © 2023 Pamphlett and Bishop.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toxic and essential metals in human striated muscle. In this muscle from a person with no neurological disorder, essential elements, such as copper (Cu), phosphorus (P), selenium (Sn) and zinc (Zn) are present in all myofibres. Some toxic metals, such as silver (Ag) and cadmium (Cd) are also seen in most myofibres. The toxic metals lead (Pb), cobalt (Co), chromium (Cr) and tin (Sn) are present in the fibrous connective tissue between muscle fascicles, which is supplied with large blood vessels. Iron (Fe) is present in blood vessels because of the high iron content of red blood cells. Method: LA-ICP-MSI as used in (26).