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. 2023 Jun 23;14:1173779. doi: 10.3389/fneur.2023.1173779

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Copyright © 2023 Pamphlett and Bishop.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toxic metals in a patient with concurrent ALS and MS. (A) Most locus ceruleus neurons contain dense black AMG™ (closed arrowheads). Some neurons have no (open arrowhead) or only slight (arrow) AMG™ staining. (B) A corticomotoneuron cell body has AMG™ in both the lipofuscin (closed arrowhead) and in the remaining perikaryon (open arrowhead). (C) One slightly shrunken spinal motor neuron has AMG™ in the perikaryon (closed arrowhead) and in its processes (open arrowheads). An adjacent motor neuron (arrow) contains no AMG™ (arrow). (D) Brain microvessels have AMG™ in their walls (closed arrowhead). Nearby oligodendrocytes or pericytes have small paranuclear AMG™ deposits (open arrowheads). Methods: A–D (18). Bars = 20 μm.