Fig 3. Importance scores of real and decoy SNPs for malignant melanoma PRS estimation by pan-cancer MTL.

(A) Manhattan plots of real SNPs (black and grey dots) and decoy SNPs (orange dots) by their importance scores. (B) density plots of the importance scores of real SNPs (black curve) and decoy SNPs (orange curve). An estimated FDR of 5% (3091 decoy SNP to 59,350 real SNPs) was reached at the importance score threshold of 0.52 × 10⁻³ (blue dotted line). No decoy SNPs and 48 real SNPs had importance scores above the threshold of 3.25 × 10⁻³ for an estimated 0.1% FDR (purple dotted line).