Table 4.
Laboratory findings of inpatients with COVID-19 with peripheral nervous system (PNS) symptoms
| Median (range) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (N=1248) | ICU-Admitted (N=387) | Not ICU-Admitted (N=861) | ||||||||||
| Characteristic [N of available/Checked data in total] | Without PNS symptoms (N =1164) | With PNS symptoms (N=84) | Wilcoxon test Z score | P a | Without PNS symptoms (N=362) | With PNS symptoms (N=25) | Wilcoxon test Z score | P a | Without PNS symptoms (N=802) | With PNS symptoms (N=59) | Wilcoxon test Z score | P a |
| Count, ×109/l | ||||||||||||
| White blood cell [1220] | 6.6 (0.9–69.7) | 5.9 (1–17.1) | −1.68 | 0.047 | 7.5 (1.5–31.3) | 7.6 (1–16) | −0.39 | 0.346 | 6.35 (0.9–69.7) | 5.8 (2.8–17.1) | −1.71 | 0.044 |
| Neutrophil [1190] | 4.9 (0.3–83.8) | 4.53 (0.7–75.4) | −1.16 | 0.246 | 5.94 (0.3–28.5) | 6.1 (0.7–14.6) | −0.01 | 0.497 | 4.5 (0.3–83.8) | 4.16 (1.7–75.4) | −1.35 | 0.088 |
| Lymphocyte [1189] | 0.9 (0–199) | 0.9 (0.1–17.8) | 0.35 | 0.362 | 0.8 (0.1–199) | 0.7 (01–2.8) | −1.40 | 0.081 | 1 (0–63.4) | 1.1 (0.2–17.8) | 1.32 | 0.094 |
| Platelet [1215] | 201 (0.6–755) | 191 (52–537) | −0.56 | 0.286 | 194 (25–755) | 170 (52–428) | −1.16 | 0.122 | 205 (0.6–737) | 206 (56–537) | 0.004 | 0.498 |
| ESR, mm/h [93] | 67 (2–120) | 45.5 (7–120) | −0.82 | 0.205 | 77 (2–120) | N/A | N/A | N/A | 55.5 (6–120) | 45.5 (7–120) | −0.53 | 0.299 |
| CRP, mg/l [797] | 83.4 (0.07–2200) | 54.7 (1–283.9) | −2.11 | 0.017 | 141 (1.2–400) | 82.3 (2.4–283.9) | −2.10 | 0.018 | 56.5 (0.07–2200) | 40.2 (1–277) | −1.10 | 0.136 |
| D-dimer, mg/l [659] | 1.33 (0.13–5000) | 1.03 (0.22–2970) | −1.5 | 0.067 | 1.52 (0.19–5000) | 2.00 (0.3–2670) | 0.44 | 0.331 | 1.25 (0.13–5000) | 0.83 (0.22–2970) | −2.10 | 0.018 |
| Fibrinogen, mg/dl [118] | 480 (2–6455) | 542 (230–860) | 1.4 | 0.080 | 481.5 (2–7470) | 763 (498–860) | 2.48 | 0.007 | 478 (216–6455) | 444 (230–642) | −0.79 | 0.215 |
| Ferritin, ng/ml [564] | 373 (0.31–7500) | 334.4 (11–2561) | −1.38 | 0.083 | 487 (2–7470) | 675.6 (86.4–2561) | 0.82 | 0.208 | 305.3 (0.31–7500) | 196 (11–1561.1) | −1.86 | 0.032 |
| LDH, U/L [465] | 296 (1.13–4706) | 289 (115–640) | −0.060 | 0.476 | 370 (7.6–4706) | 374 (167–640) | −0.18 | 0.430 | 270 (1.13–1644) | 250 (115–629) | −0.19 | 0.424 |
| CK, U/L [292] | 119 (2–60 000) | 110 (20–574) | −0.16 | 0.436 | 204 (14–60 000) | 279 (20–574) | −0.37 | 0.357 | 86 (1–60 000) | 72.5 (34–543) | 0.49 | 0.314 |
| Aminotransferase, U/L | ||||||||||||
| Alanine (ALT) [1075] | 24 (1–2090) | 26 (5–182) | 0.61 | 0.272 | 25 (3–2090) | 23 (5–182) | 0.34 | 0.368 | 23 (1–1276) | 27 (6–152) | 0.48 | 0.315 |
| Aspartate (AST) [1076] | 34 (3–10 750) | 33 (8–363) | −0.36 | 0.365 | 40 (9–141) | 40 (8–363) | 0.41 | 0.408 | 31 (3–1193) | 32 (11–172) | −0.11 | 0.455 |
| BUN, mg/dl [1204] | 20 (0.59–171) | 16 (4–91) | −3.19 | 0.0007 | 26 (0.9–141) | 18 (6–91) | −1.34 | 0.090 | 18 (0.59–171) | 14 (4–83) | −2.88 | 0.002 |
| Creatinine, mg/dl [1211] | 1.01 (0.28–52) | 0.86 (0.2–7.98) | −3.18 | 0.0007 | 1.14 (0.32–18) | 0.99 (0.2–3.43) | −2.14 | 0.016 | 0.97 (0.28–52) | 0.85 (0.34–7.98) | −2.32 | 0.010 |
| PT, s [635] | 10.9 (1.43–96.5) | 10.95 (9.6–58.8) | −0.45 | 0.326 | 11.1 (9.3–79) | 10.9 (9.6–58.8) | −0.67 | 0.251 | 10.8 (1.43–96.5) | 11 (9.9–33.3) | 0.09 | 0.465 |
| PTT, s [384] | 32.8 (0.9–150) | 31.2 (23.1–147.8) | −1.32 | 0.094 | 34.1 (20.7–150) | 32.1 (23.1–147.8) | −1.25 | 0.105 | 31.3 (0.9–139) | 31 (25.9–42.8) | −0.50 | 0.309 |
| INR [637] | 1.0 (0.37–38.4) | 1 (0.46–6.2) | −0.73 | 0.234 | 1 (0.9–8) | 1.0 (0.46–6.2) | −0.87 | 0.192 | 1 (0.37–38.4) | 1 (0.9–3.4) | −0.24 | 0.406 |
a
P values indicate differences between inpatients with COVID-19 without versus with PNS symptoms, and P less than 0.05 was considered statistically significant using the Wilcoxon Two-Sample Test.
BUN, blood urea nitrogen; CK, creatine kinase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; INR, International normalized ratio; LDH, lactate dehydrogenase; PT, prothrombin time; PTT, partial thromboplastin time.
Bold values signify statistical significance.