Table 5.
Laboratory findings of inpatients with COVID-19 with skeletal muscle injury
| Median (range) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (N=292) | ICU-Admitted (N=128) | Not ICU-Admitted (N=164) | ||||||||||
| Characteristic [N of available/Checked data in total] | Without skeletal muscle injury (N=262) | With skeletal muscle injury (N=30) | Wilcoxon test Z score | P a | Without skeletal muscle injury (N=111) | With skeletal muscle injury (N=17) | Wilcoxon test Z score | P a | Without skeletal muscle injury (N=151) | With skeletal muscle injury (N=13) | Wilcoxon test Z score | P a |
| Count, ×109/l | ||||||||||||
| White blood cell [1220] | 6.5 (1.3–23.4) | 5.25 (2.6–16.7) | −1.59 | 0.055 | 7.2 (2.5–23.1) | 6.1 (2.9–16.7) | −0.94 | 0.174 | 6.3 (1.3–23.4) | 4.9 (2.6–12.6) | −1.69 | 0.045 |
| Neutrophil [1190] | 4.9 (0.5–83.8) | 3.6 (0.5–14.19) | −2.16 | 0.015 | 5.5 (0.9–22.5) | 4.51 (0.5–14.19) | −1.27 | 0.102 | 4.4 (0.5–83.8) | 2.85 (1.1–9.86) | −2.29 | 0.011 |
| Lymphocyte [1189] | 0.9 (0.1–17.8) | 0.9 (0.2–199) | 0.70 | 0.243 | 0.7 (0.1–15.6) | 0.9 (0.2–199) | 1.03 | 0.150 | 1 (0.1–17.8) | 1.15 (0.4–7.7) | 0.69 | 0.245 |
| Platelet [1215] | 194 (6.4–598) | 191 (61–572) | −1.08 | 0.140 | 177 (34–515) | 192.5 (114–572) | 0.03 | 0.488 | 200 (6.4–598) | 175 (62–245) | −1.40 | 0.080 |
| ESR, mm/h [93] | 54 (2–120) | 79 (67–94) | 1.13 | 0.128 | 56 (2–120) | 85 (76–94) | 0.52 | 0.301 | 46 (7–120) | 74.5 (67–82) | 0.97 | 0.166 |
| CRP, mg/l [797] | 79.4 (0.5–2200) | 105.1 (24.1–292.6) | 1.47 | 0.070 | 147 (2–400) | 165.15 (30.1–292.6) | 0.80 | 0.212 | 52.1 (0.5–2200) | 77.6 (24.1–146) | 0.646 | 0.259 |
| D-dimer, mg/l [659] | 1.34 (0.13–5000) | 1.08 (0.3–1240) | −1.21 | 0.112 | 1.55 (0.23–5000) | 1.32 (0.3–1240) | −1.27 | 0.103 | 1.17 (0.13–3650) | 0.89 (0.36–571) | −0.64 | 0.261 |
| Fibrinogen, mg/dl [118] | 509 (2–6455) | 542 (294–734) | 0.41 | 0.341 | 530 (2–813) | 561 (478–734) | 0.18 | 0.427 | 476.5 (230–6455) | 418 (294–542) | −0.69 | 0.244 |
| Ferritin, ng/ml [564] | 378.9 (0.83–7470) | 589.5 (146–4625) | 2.39 | 0.008 | 502 (2–7470) | 598 (227–2121) | −0.21 | 0.418 | 272.4 (0.83–5554) | 581 (146–4625) | 2.69 | 0.004 |
| LDH, U/L [465] | 295.5 (105–4706) | 440 (223–986) | 3.31 | 0.0005 | 372 (106–4706) | 640 (325–986) | 2.53 | 0.006 | 264 (105–960) | 292 (223–425) | 1.00 | 0.159 |
| CK, U/L [292] | 99 (2–60 000) | 366 (201–1922) | 5.62 | <0.0001 | 156.5 (14–60 000) | 393 (201–1922) | 2.91 | 0.002 | 72 (3.0–159) | 313 (218–846) | 4.55 | <0.0001 |
| Aminotransferase, U/L | ||||||||||||
| Alanine (ALT) [1075] | 28 (3–433) | 53 (10–330) | 3.44 | 0.0003 | 32 (3–433) | 48 (10–330) | 1.29 | 0.099 | 27 (3–171) | 53 (28–104) | 3.42 | 0.0003 |
| Aspartate (AST) [1076] | 39.5 (11–2640) | 57.5 (20–359) | 3.36 | 0.0004 | 48 (13–2640) | 63 (20–359) | 1.38 | 0.083 | 33 (11–223) | 53 (28–104) | 3.05 | 0.001 |
| BUN, mg/dl [1204] | 20 (0.9–171) | 16 (6–56) | −1.59 | 0.056 | 26 (0.9–141) | 16 (6–38) | −2.85 | 0.002 | 17 (3–171) | 16 (7–56) | 0.27 | 0.392 |
| Creatinine, mg/dl [1211] | 1 (0.42–19.07) | 0.99 (0.2–7.57) | 0.06 | 0.474 | 1.2 (0.42–18) | 0.97 (0.2–2.16) | −1.71 | 0.043 | 0.92 (0.45–19.07) | 1.17 (0.67–7.57) | 1.53 | 0.063 |
| PT, s [635] | 11.1 (8.9–46) | 10.9 (9.6–34) | −0.90 | 0.183 | 11.2 (9.3–44.8) | 10.9 (9.6–11.9) | −1.56 | 0.060 | 11 (8.9–46) | 11 (10–34) | 0.28 | 0.391 |
| PTT, s [384] | 32.8 (20–147.8) | 31.9 (26.8–112.7) | −0.01 | 0.496 | 33.4 (20.7–147.8) | 31.7 (26.8–112.7) | −0.53 | 0.297 | 32.2 (20–83) | 35 (30.4–67.2) | 0.95 | 0.172 |
| INR [637] | 1 (0.9–4.8) | 1 (0.9–3.5) | −0.17 | 0.431 | 1 (0.9–3) | 1.05 (1–1.1) | −0.14 | 0.446 | 1 (0.9–4.8) | 1 (0.9–3.5) | −0.20 | 0.422 |
a
P values indicate differences between inpatients with COVID-19 without versus with skeletal muscle injury, and P less than 0.05 was considered statistically significant using the Wilcoxon Two-Sample Test.
BUN, blood urea nitrogen; CK, creatine kinase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; INR, International normalized ratio; LDH, lactate dehydrogenase; PT, prothrombin time; PTT, partial thromboplastin time.
Bold values signify statistical significance.