Figure 8.

Preparation and characterization of olaparib-loaded micelles (polymer/drug ratio of 10/1) with different morphologies. a) Cryo-TEM images of olaparib-loaded micelles at 1 and 72 h after hydration. Change of b) intensity weighted size distribution and c) particle size, PDI, and drug concentration of olaparib-loaded micelles over time. d) Olaparib release profile from sphere- and worm-like micelles. Olaparib-loaded micelles were prepared using the thin film hydration method. While keeping drug loading content, the olaparib micelles elongated until forming worm-like structure by 72 h. Olaparib micelles did not exhibit significant changes in the drug release profile. Errors shown correspond to three standard deviations of uncertainty.