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. 2023 Jul 7;11(13):e15767. doi: 10.14814/phy2.15767

FIGURE 1.

FIGURE 1

Changes in prothrombin time and blood pressure in mice treated with warfarin and N‐acetylcysteine (NAC). (a) Changes in prothrombin time, calculated as sINR, in 5/6 nephrectomy (5/6NE) C57BL/6 mice treated per os with warfarin 1.0 mg/kg/day alone (circle, n = 7) or with warfarin 1.0 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE C57BL/6 mice. (b) Changes in systolic blood pressure (upper 3 lines) and diastolic blood pressure (lower 3 lines) in 5/6 nephrectomy (5/6NE) C57BL/6 mice treated per os with warfarin 1.0 mg/kg/day alone (circle, n = 7) or with warfarin 1.0 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE C57BL/6 mice. (c) Changes in prothrombin time, calculated as sINR, in 5/6NE 129S1/SvImJ mice treated per os with warfarin 0.5 mg/kg/day alone (circle, n = 7) or with warfarin 0.5 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE 129S1/SvImJ mice. (d) Changes in systolic blood pressure (upper 3 lines) and diastolic blood pressure (lower 3 lines) in 5/6NE 129S1/SvImJ mice treated per os with warfarin 0.5 mg/kg/day alone (circle, n = 7) or with warfarin 0.5 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE 129S1/SvImJ mice. *p < 0.005 as compared to control mice, # p < 0.05 as compared to warfarin‐only treated mice.