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. 2023 Jul 7;11(13):e15767. doi: 10.14814/phy2.15767

FIGURE 2.

FIGURE 2

Changes in serum creatinine and hematuria in mice treated with warfarin and N‐acetylcysteine (NAC). (a) Changes in serum creatinine in 5/6 nephrectomy (5/6NE) C57BL/6 mice treated per os with warfarin 1.0 mg/kg/day alone (circle, n = 7) or with warfarin 1.0 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE C57BL/6 mice. (b) Changes in hematuria in 5/6 nephrectomy (5/6NE) C57BL/6 mice treated per os with warfarin 1.0 mg/kg/day alone (circle, n = 7) or with warfarin 1.0 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE C57BL/6 mice. (c) Changes in serum creatinine in 5/6NE 129S1/SvImJ mice treated per os with warfarin 0.5 mg/kg/day alone (circle, n = 7) or with warfarin 0.5 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE 129S1/SvImJ mice. (d) Changes in hematuria in 5/6NE 129S1/SvImJ mice treated per os with warfarin 0.5 mg/kg/day alone (circle, n = 7) or with warfarin 0.5 mg/kg/day and NAC 30 mg/kg/day (triangle, n = 7). Control (square, n = 6) are vehicle‐treated 5/6NE 129S1/SvImJ mice. Hematuria was measured by Siemens Multistix 5 (Siemens Healthcare Diagnostics Inc, Tarrytown, NY) and expressed in a semiquantitative scale from 0 to 3, where score 0 is absent, 1+ is trace, 2+ is moderate and 3+ is large. *p < 0.005 as compared to control mice, # p < 0.05 as compared to warfarin‐only treated mice.