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. 2023 Jun 1;42(28):2207–2217. doi: 10.1038/s41388-023-02737-z

Fig. 4. RMC-6272 causes apoptosis through a MCL1 dependent mechanism.

Fig. 4

A Immunoblot of indicated proteins using lysates from MCF-7 cells treated with RMC-6272 at indicated concentration for 24 h. CL-PARP, cleaved PARP. Image represents two independent experiments. B MCF-7 or ZR751 cells overexpressing V5-tagged Luciferase (control) or V5-tagged MCL1 treated with RMC-6272 at indicated concentration for 24 h, and the lysates were immunoblotted for indicated proteins. Image represents at least two independent experiments. C Quantification of Cl-PARP compared to vinculin loading control in (B).