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. 2023 Jul 7;13:11006. doi: 10.1038/s41598-023-35827-9

Table 2.

Morphomigrational description of fragments K1, H1–H5.

Fragment of sequence Parameter Coarse-grain description of numerical values What does the quantitative parameter inform about Morphomigrational behaviour
K1 sMM Moderate and high, sign does not change Displacement perpendicular to major axis, always on the same side of it Perpendicular displacement [frames 16–19] and askew displacement [frame 20]
α Low, sign might change Movement in particular direction. Changing sign informs about no visible bias in the clockwise nor anti-clockwise direction
Δϕ Very low, sign might change No rapid changes of cell shape
ε Moderate, increasing Moderately elongated
H1 sMM Very low and low, sign does not change Displacement along the major axis Lateral displacement [frames 3, 5, 6]
α Low, sign might not change Movement in particular direction. Changing sign informs about no visible bias in the clockwise nor anti-clockwise direction
Δϕ Very low and low, sign might not change Cell shape rotates slightly anti-clockwise
ε Moderate, constant Moderately elongated cell
sMM Very low and low, the same sign Displacement along the major axis With occasional lateral U-turns [frames 4, 7]
α Low → high/very high, sign might change Cell performs the turn back
Δϕ Very low and low, the same sign Barely noticeable anti-clockwise turn of the shape
ε Moderate, constant Moderately elongated cell
H2 sMM Moderate and low, changing sign Displacement in various directions regarding M.A. Rounded cell with chaotic movement [frames 12–14]
α High and very high, changing sign Nondirectional movement
Δϕ Low, moderate and high, the same sign Shape changes its arrangement in clockwise direction
ε Moderate and low, decreasing Rounded or regular polygonal shape
H3 sMM Very low → high, the same sign Rapid change of sMM from lateral to perpendicular movement Rear protrusion retraction with directional displacement. Cell geometry changes from parallel to perpendicular to movement direction [frames 22–23]
α Low, changing sign Movement in particular direction. Changing sign informs about no visible bias in the clockwise nor anti-clockwise direction
Δϕ High → low, the same sign Incidental rotation of cell shape, further conservation of this arrangement on 2D plane
ε Moderate, stable Moderately elongated cell
H4 sMM Moderate and high, changing sign Protrusions are created perpendicularly and askew to M.A. on both sides of it. The same sign in the end of sequence indicates perpendicular displacement Perpendicular/askew stretching ended with perpendicular displacement [frames 24–28]
α Very high, moderate and low sign does not change Chaotic movement ended by directional movement
Δϕ Very low and low, changing sign Shape slightly changes its arrangement first anti-clockwise and then clockwise
ε Moderate, increasing Cell slightly stretches itself while still being moderately elongated
H5 sMM Moderate, the same sign Displacement askew to the major axis constantly on the same side of M.A. Lateral stretching with perpendicular displacement [frames 31–34]
α High → low, changing sign Cell first changes movement direction (high α) and then stabilizes it (low α)
Δϕ Low and very low, mostly the same sign Cell arrangement slightly changes in the beginning and stabilizes itself in next frames
ε Moderate, increasing Cell stretches itself