Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 7;14:4036. doi: 10.1038/s41467-023-39690-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Superposition of structures of AR3C-class bNAbs AR3C, AR3A, AR3B, AR3D, HEPC3, HEPC74, and AT1209 (PDB entries: 4MWF, 6BKB, 6BKC 6BKD 6MEI, 6MEH, 7T6X, respectively) on the E1E2 complex (PDB: 7T6X) which bind to the same AR3 epitope on the neutralizing face of E2. Only the variable heavy (VH) regions of the bNAbs are shown for clarity. Left panel: superposition of the CDRH2 (Kabat: 50-65). The exceptionally long CDRH2 of AT1209 is highlighted in orange. Right panel: superposition of the CDRH3 loops (Kabat: 91-104) of mature AR3C-class bNAbs with a bent (AR3A, AR3B, AR3C, AR3D, and AT1209) and straight CDRH3 (HEPC3 and HEPC74). b Length distribution of human CDRH2 (left) and CDRH3 (right). Human CDRH2 lengths were extracted from the online abYsis system (http://www.bioinf.org.uk/abysis/) using the Kabat numbering scheme Kabat and National Institutes of Health (U.S.). Highlighted are the relative positions of the AR3C-class antibodies.