Fig. 6.

Tau oligomers and tau fibrils do not trigger evident neurodegeneration. a Quantification of the area of the DAPI-positive pyramidal layer in the dorsal hippocampus of PS19 mice 3 months after injection. b Quantification of the CA area of the dorsal hippocampus of PS19 mice 3 months after injection. c Representative images of Bassoon-positive pre-synapses (green) and PSD95-positive post-synapses (magenta) in the stratum radiatum of PS19 mice 3 months after injection. Scale bar = 4 µm. d Quantification of Bassoon-positive pre-synaptic density in the stratum radiatum of PS19 mice 3 months after injection. e Quantification of PSD95-positive post-synaptic density in the stratum radiatum of PS19 mice 3 months after injection. Data represented as mean ± SEM, Kruskal–Wallis, non-significant for (a, b). Data represented as mean ± SEM, one-way ANOVA, non-significant for (d, e)