Table 1. Years of Life Lost Due to Unintentional Opioid Toxicity in the US by Age and Sex, 2019 to 2021.

Age groups, y	2019, No.				2020, No.				2021, No.
	Unintentional opioid-related deaths	Deaths per million	YLL	YLL per 1000	Unintentional opioid-related deaths	Deaths per million	YLL	YLL per 1000	Unintentional opioid-related deaths	Deaths per million	YLL	YLL per 1000
Overall	45 315	184.9	1 772 030	7.2	63 946	259.9	2 521 813	10.2	75 477	302.9	2 922 497	11.7
15-19	515	24.5	31 097	1.5	1196	57.1	72 260	3.4	1371	63.6	83 193	3.9
20-29	8786	194.6	468 243	10.4	12 377	276.1	660 835	14.7	13 035	296.8	695 949	15.8
30-39	13 234	299.6	596 845	13.5	18 831	421.6	848 304	19.0	21 741	478.9	979 090	21.6
40-49	9623	238.7	347 225	8.6	13 741	341.1	497 694	12.4	16 650	407.2	604 488	14.8
50-59	8811	208.0	242 351	5.7	11 768	280.2	322 987	7.7	14 581	343.3	399 710	9.4
60-74	4346	83.5	86 269	1.7	6033	113.1	119 732	2.2	8099	147.5	160 068	2.9
Males	32 041	264.1	1 224 382	10.1	45 852	376.4	1 765 682	14.5	53 797	433.7	2 030 032	16.4
15-19	370	34.4	21 846	2.0	879	82.2	51 957	4.9	962	87.3	56 926	5.2
20-29	6388	276.9	332 428	14.4	9120	398.1	475 773	20.8	9475	423.9	493 409	22.1
30-39	9442	424.6	414 342	18.6	13 628	605.5	597 869	26.6	15 685	683.8	688 162	30.0
40-49	6878	344.0	241 137	12.1	9756	488.3	342 525	17.1	11 853	579.1	417 216	20.4
50-59	5947	286.9	157 236	7.6	8167	397.2	215 820	10.5	10 037	476.4	264 712	12.6
60-74	3016	122.8	57 394	2.3	4302	171.0	81 738	3.2	5785	220.8	109 606	4.2
Females	13 274	107.3	547 648	4.4	18 094	145.6	756 130	6.1	21 680	173.3	892 466	7.1
15-19	145	14.1	9251	0.9	317	30.9	20 303	2.0	409	38.8	26 266	2.5
20-29	2398	108.6	135 815	6.2	3257	148.6	185 062	8.4	3560	165.1	202 540	9.4
30-39	3792	172.9	182 503	8.3	5203	234.8	250 435	11.3	6056	269.6	290 928	13.0
40-49	2745	135.0	106 088	5.2	3985	196.3	155 169	7.6	4797	235.0	187 272	9.2
50-59	2864	132.4	85 114	3.9	3601	168.0	107 167	5.0	4544	212.3	134 998	6.3
60-74	1330	48.4	28 876	1.1	1731	61.4	37 994	1.3	2314	80.6	50 463	1.8

Abbreviation: YLL, years of life lost.