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. 2023 Jul 7;6(7):e2322131. doi: 10.1001/jamanetworkopen.2023.22131

Figure 2. Association Between Biomarkers and Death or Neurodevelopmental Impairment.

Figure 2.

Y-axis shows unadjusted P values from univariate analyses, with individual biomarkers along the x-axis. Relative risks and confidence intervals for these P values are in eTable 1 in Supplement 2. Biomarkers across all categories (anti-inflammatory, pro-inflammatory, brain-specific, and growth categories) at each time point were associated with death or neurodevelopmental impairment at 2 years. P values are not indicative of effect size. BDNF indicates brain-derived neurotrophic factor; GFAP, glial fibrillary acidic protein; ICAM-1, intercellular adhesion molecule 1; IFN-γ, interferon-γ; IL, interleukin; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NCAM-1, neural cell adhesion molecule; NGB, neuroregulin-1-b-1; NSE, neuron-specific enolase; s100b, S100 calcium-binding protein B; TNF-α, tumor necrosis factor–α; UCHL1, ubiquitin carboxy-terminal hydrolase-L1; VCAM, vascular cell adhesion molecule; VEGF, vascular endothelial growth factor.