Table 1.
Univariate and multivariate Cox regression analysis of OS in the whole cohort (102 GG4 cases)
| Characteristic | N | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| CW | 102 | ||||||
| 0; untreated | 63 | – | – | – | – | ||
| 1; treated | 39 | 0.53 | 0.34, 0.81 | 0.003 | 0.62 | 0.40, 0.96 | 0.032 |
| Age | 102 | 1.01 | 1.0, 1.04 | 0.2 | |||
| EOR | 102 | 0.92 | 0.89, 0.96 | < 0.001 | 0.94 | 0.91, 0.98 | 0.002 |
| Localization | 102 | ||||||
| 0; precentral | 41 | – | – | ||||
| 1; postcentral | 21 | 1 | 0.58, 1.72 | > 0.9 | |||
| 2; temporoinsular | 40 | 1.09 | 0.70, 1.71 | 0.7 | |||
| Ki67 | 102 | 1.01 | 1.00, 1.02 | 0.14 | |||
| IDH mutational status | 102 | ||||||
| 0; unmutated | 94 | – | – | ||||
| 1; mutated | 8 | 0.65 | 0.32, 1.35 | 0.3 | |||
| Side | 102 | ||||||
| 0; left | 54 | – | – | ||||
| 1; right | 48 | 1.2 | 0.81, 1.80 | 0.4 | |||
| Preoperative volume | 102 | 1.01 | 1.00, 1.02 | 0.033 | 1.01 | 1.00, 1.02 | 0.25 |
| Extent of resection_2 categories | 102 | ||||||
| 0; ≤99% | 52 | – | – | ||||
| 1; ≥100% | 50 | 0.81 | 0.54, 1.20 | 0.3 | |||
| MGMT status | 102 | ||||||
| 0; unmethylated | 40 | – | – | ||||
| 1; methylated | 62 | 0.44 | 0.28, 0.68 | < 0.001 | 0.47 | 0.30,0.74 | < 0.001 |
| Gender: female | 102 | 1.18 | 0.76, 1.82 | 0.5 | |||
CI confidence interval, HR hazard ratio, EOR extent of resection. In bold p-value < 0.05