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. 2023 Jul 8;22:99. doi: 10.1186/s12944-023-01855-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Hepatocyte conditional knockout of HO-1 aggravates HFD-induced NASH. (A) Western blot analysis of HO-1 in liver tissue. β-Actin served as the loading control. (B) Images of HO-1 (×400 magnification) staining of representative liver sections in WT and HO-1^HEPKO mice. (C) Images of H&E (×200 magnification) staining of representative liver sections and (D) the NAFLD activity score. (E) Images of Masson (×200 magnification) staining of representative liver sections and (F) the Metavir score. (G, H) Images and IOD of Oil Red O (×200 magnification) staining of representative liver sections were obtained from each group. Values are the mean ± SD (n = 6 per group). *P < 0.05, **P < 0.01 compared to the WT ND group; #P < 0.05, ##P < 0.01 compared to the WT HFD group