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. 2023 Jul 8;14:88. doi: 10.1186/s40104-023-00893-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Comparison of the molecular mechanism of coarse wool follicle morphogenesis between ALC and coarse wool lamb breeds. A Analysis of top GO terms and KEGG pathways (Metascape database: http://www.metascape.org/) by using up and down-regulated differentially expressed genes in ALC wool lamb skin. −log10 of the P value as were taken at the X-axis for enrichment analysis. The up-regulated differentially expressed genes in embryos are shown in red bars, while the blue bars indicate the at-birth or adulthood stage. The numbers represent the number of genes enriched in each term. B The overlap of up-regulated DEGs in hair follicle morphogenesis process between ALC wool lambs and coarse wool lamb breeds. C The overlap of up-regulated DEGs in Wnt signal pathway between ALC wool lambs and coarse wool lamb breeds. D Expression analysis of candidate genes among coarse and fine wool breeds at different developmental stages. ^*0.01 < P < 0.05, ^**P < 0.01, ^***P < 0.001. E Analysis of key protein interactions network by using online tool (GeneMANIA: http://genemania.org/)