Table 1.
Demographic and clinical characteristics of cohort
| Clinical feature | LMD (n = 49) | No LMD (n = 746) | p value† |
|---|---|---|---|
| Age in yearsa [Median (IQR)] | 52 (45, 61) | 60 (51, 68) | 0.0002 |
| Sex | 0.08 | ||
| Male (%) | 18 (37) | 374 (50) | |
| Female (%) | 31 (63) | 372 (50) | |
| Primary site of cancer | <0.0001 | ||
| Lung (%) | 17 (35) | 386 (52) | |
| Breast (%) | 15 (31) | 127 (17) | |
| Skin (melanoma) (%) | 8 (16) | 108 (14) | |
| Genitourinary (%) | 0 (0) | 60 (8) | |
| Colon/rectal (%) | 6 (12) | 40 (5) | |
| Esophageal (%) | 0 (0) | 17 (2) | |
| Gynecologic (%) | 2 (4) | 4 (1) | |
| Unknown/other (%) | 1 (2) | 4 (1) | |
| Number of metastases [Median (IQR)] | 2 (1, 4) | 2 (1, 3) | 0.34 |
| Distant failure (%) | 35 (71) | 311 (42) | <0.0001 |
| Surgery (%) | 17 (35) | 229 (31) | 0.63 |
| Before SRS (%) | 17 (35) | 204 (27) | 0.32 |
| After SRS (%) | 0 (0) | 25 (3) | 0.39 |
| Whole brain radiation (%) | 31 (63) | 377 (51) | 0.10 |
| Time to LMD or censoring (months) [median (IQR)] | 7.4 (3.3, 15.4) | 7.5 (3.6, 17.5) | 0.65 |
IQR interquartile range, SRS stereotactic radiosurgery, LMD leptomeningeal dissemination
a
On date of first stereotactic radiosurgery
†
Comparisons between the two groups made with Fisher’s exact test for categorical variables and Wilcoxon rank sum test for continuous variables