Fig. 2.

3D modeling of the MCM complex dimer and the identified variants. A 3D-model of the MCM hexamer complex visualized in PyMOL Molecular Graphics (PDB: 7W1Y). The zinc finger domains are depicted in orange (MCM2), blue (MCM4) and pink (MCM6) The MCM6 OB-fold domain is depicted in light pink. The zinc atoms are depicted as green balls. B Inset hexamer dimer interface showing the close proximity between the zinc finger domains of MCM2, MCM4 and MCM6. C Left panels show the WT amino acid residue (purple), the substitution as observed in the affected individuals is shown in the right panels