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. 2023 Jul 8;14(7):408. doi: 10.1038/s41419-023-05938-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap of 10 dysregulated expressed ubiquitination-related genes in NAT, LN+ CA and LN+, as detected by qPCR. NAT, normal adjacent tissues; LN+ CA, BCa tissues with lymphatic metastasis; LN+, metastatic LNs. B Histogram showing the analysis of UBE2S mRNA expression in 5 paired BCa tissues detected by qPCR. C Representative images of immunohistochemistry staining for UBE2S expression in Cohort 1, which consisted of 59 NAT and 210 BCa tissues. Scale bars: black, 200 μm; red, 50 μm. D Protein levels of UBE2S in Cohort 1. E The relative mRNA expression of UBE2S in NAT and BCa tissues from the TCGA database. F Expression of UBE2S in LN− CA and LN + CA in the GSE48277 database. LN- CA, BCa tissues without lymphatic metastasis. G, H Comparison of UBE2S expression in BCa tissues without metastasis (M−) and with metastasis (M+) from TCGA and GSE48277 databases. I–L Comparison of UBE2S expression in NMIBC and MIBC tissues from Cohort 1, GSE31684, GSE48277 and GSE120736 databases. NMIBC nonmuscle-invasive bladder cancer, MIBC muscle-invasive bladder cancer. M–P Comparison of UBE2S expression in LG and HG BCa tissues from Cohort 1, TCGA, GSE31684 and GSE120736 databases. LG low-grade, HG high-grade. Q, R Kaplan‒Meier curves showing the overall survival (OS) and disease-free survival (DFS) of BCa patients with high UBE2S expression and low UBE2S expression in Cohort 1). *P < 0.05 and **P < 0.01.