Table 1. Lipedema clinical characteristics considered in physical examination.

The table summarizes the typical features identified during a physical examination and the characteristic signs of lipedema [3].

Characteristics
Physical examination	Disproportionately increased, loose connective (adipose) tissue on the limbs
	Symmetric tissue
	Palpable tissue nodules beneath the skin
	Tenderness or painful tissue; not always
	Symmetrical limb swelling; pitting or non-pitting
	Hands and feet not affected
	Mobility issues
	Changes in skin texture: thicker or lumpier than normal, similar to an orange peel
Signs	Persistent enlargement of the legs despite elevation
	Easy bruising and/or vascular fragility
	Stemmer-Kaposi sign: inability to pinch and lift the skin on the upper surface of the second toe or finger