Fig. 2.

a Annual healthcare costs for all patients with SCD with recurrent VOCs, the subgroup of patients who continued to experience ≥ 2 VOCs per year during the variable-length follow-up, and matched controls, as well as b payer-specific annual healthcare costs for all patients with SCD with recurrent VOCs and the subgroup of patients who continued to experience ≥ 2 VOCs per year during the variable-length follow-up. ^aOutpatient visits/encounters included emergency department, physician office, laboratory, and other outpatient visits/encounters. PPPY per patient per year; SCD sickle cell disease; VOC vaso-occlusive crisis