Table 2.
Clinical complications in patients with SCD with recurrent VOCsa
| Patients with SCD with recurrent VOCs (N = 3420) | |
|---|---|
| Clinical complication, n (%)b | |
| Acute infections | 2696 (78.8) |
| Chronic lung disease | 1653 (48.3) |
| Asthma | 1553 (45.4) |
| Mental health complications | 1307 (38.2) |
| Anxiety | 872 (25.5) |
| Depression | 960 (28.1) |
| Cardiovascular complications | 1232 (36.0) |
| Cardiomegaly | 947 (27.7) |
| Heart failure | 355 (10.4) |
| Pulmonary hypertension | 417 (12.2) |
| Bone and joint problemsc | 946 (27.7) |
| Avascular necrosis/osteonecrosis | 920 (26.9) |
| Chronic pain | 908 (26.5) |
| Iron overload | 635 (18.6) |
| Hypercoagulable state | 581 (17.0) |
| Gallbladder diseased | 573 (16.8) |
| Gallstones | 531 (15.5) |
SCD sickle cell disease; VOC vaso-occlusive crisis
aData were assessed during the variable-length follow-up, beginning on the index date and ending on the earliest date of either inpatient death, end of continuous enrollment, or end of the study period (March 1, 2020)
bClinical complications that occurred in > 10% of the patient population are presented
cBone/joint complications included avascular necrosis/osteonecrosis and osteoporosis
dGallbladder disease included chronic cholecystitis, gallstones, and other chronic gallbladder disease