Table 4.
Annual HCRU of patients with SCD with recurrent VOCs and matched controlsa
| Annual HCRU | Patients with SCD with recurrent VOCs (N = 3420) | Matched controls (N = 16,722) | p valueb | Subgroup of patients who continued to experience ≥ 2 VOCs/year (n = 2310) |
|---|---|---|---|---|
| Inpatient | ||||
| Patients with ≥ 1 admission, n (%) | 3212 (93.9) | 2068 (12.4) | < 0.0001 | 2250 (97.4) |
| Inpatient admissions PPPY, mean (SD) | 2.7 (2.9) | 0.05 (0.2) | < 0.0001 | 3.6 (3.1) |
| Total days of hospitalization, mean (SD) | 14.7 (20.1) | 1.8 (5.4) | < 0.0001 | 19.3 (22.3) |
| Outpatient visits/encounters PPPY, mean (SD) | ||||
| All outpatientc | 50.2 (48.1) | 18.8 (45.6) | < 0.0001 | 56.7 (51.2) |
| Emergency departmentd | 5.0 (8.0) | 0.6 (1.3) | < 0.0001 | 6.6 (9.3) |
| Physician officee | 11.2 (10.3) | 3.2 (3.9) | < 0.0001 | 11.9 (11.6) |
| Laboratoryf | 9.7 (9.4) | 1.7 (3.0) | < 0.0001 | 10.8 (10.1) |
| Otherg | 24.2 (35.7) | 13.3 (43.8) | < 0.0001 | 27.4 (37.8) |
| Outpatient pharmacy | ||||
| Prescriptions PPPY, mean (SD) | 35.1 (28.3) | 11.4 (21.1) | < 0.0001 | 38.5 (29.6) |
HCRU healthcare resource utilization; PPPY per patient per year; SCD sickle cell disease; SD standard deviation; VOC vaso-occlusive crisis
aData were assessed during the variable-length follow-up, beginning on the index date and ending on the earliest date of either inpatient death, end of continuous enrollment, or end of the study period (March 1, 2020)
bStatistical testing was performed only between the overall population of patients with SCD with recurrent VOCs and matched controls
cOutpatient visits/encounters were counted by identifying unique visits to a particular healthcare provider type on a particular date
dEmergency department visits were counted as the number of distinct dates with an emergency department claim
ePhysician office visits were counted as the number of distinct dates with a visit to a unique healthcare provider type in an office setting
fLaboratory visits were counted as the number of distinct dates with a visit to a laboratory
gOther outpatient visits/encounters were counted as the number of distinct dates with a visit to a unique healthcare provider type in a non-office setting (e.g., radiology, outpatient surgery, etc.)