Figure 4:

Pathology findings by screening arm with adenoma or serrated lesions over 4-7 years followed

High sensitivity fecal occult blood test (HSgFOBT); Relative Risk (RR); 95% Confidence Intervals (95% CI)

* Serrated polyp definition was based on Rex³⁶ and Gupta³⁸ definition on features of serrated lesions which are associated with advanced neoplasia. These features include proximal colon location of serrated lesions, increasing number and larger size of serrated lesions or traditional serrated adenomas histology (Appendix Table 2).

† Positive screening-colonoscopy pathology findings based on total 1761 participants randomized; 1558 participants with colonoscopies, of which 85 had initial colonoscopy after 12 months.

‡ HSgFOBT findings from follow-up colonoscopy after a positive HSgFOBT and from cross-over colonoscopy without a positive HSgFOBT based on 1762 participants randomized.