Figure 5:

Colonoscopy and HSgFOBT pathology findings from adherence over the first 4 rounds

A) Per-protocol findings for screening-colonoscopy and HSgFOBT, defined as completion of screening-colonoscopy 12 months after randomization or [1] four sequential rounds of negative HSgFOBTs, or [2] participants who had a positive HSgFOBT with proper number of preceding negative and diagnostic colonoscopy after positive HSgFOBT

B) Per-protocol findings for screening-colonoscopy and individuals who completed at least 1 but no more than 3 rounds of HSgFOBTs

C) Per-protocol findings for screening-colonoscopy and individuals who completed at least 1 but no more than 3 rounds of HSgFOBTs combined with those who sequentially completed all four rounds of HSgFOBT

D) Includes all screening in the first four rounds defined as all screening-colonoscopies as well as all HSgFOBT including crossovers