Appendix Table 2b.

Classification of adenomas for neoplastic potential in the screening-colonoscopy and HSgFOBT arm

Adenomas
Histology	Size	Number of polyps	Location	Reference	Total Findings Per Participant in Screening-Colonoscopy Arm	Total Findings Per Participant in HSgFOBT Arm
Tubular	< 10 mm	1 or 2	Any	Non-advanced (neoplasia)	293	143
Tubular	< 10 mm	≥ 3	Any	Advanced (neoplasia)*	31	23
Tubular	≥ 10 mm	≥1	Any	Advanced (neoplasia)*	73	56
Tubulovillous, villous, or high-grade dysplasia	Any	>1	Any	Advanced (neoplasia)*	24	28

High sensitivity fecal occult blood test (HSgFOBT), Hyperplastic polyps (HP), Sessile serrated lesion (SSL),Traditional serrated adenoma (TSA)

^*Advanced neoplasia classification includes colorectal cancer