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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Mater. 2023 Mar 20;22(7):818–831. doi: 10.1038/s41563-023-01472-w

Fig. 2 |. Advantages of hydrogels as a platform for RNA delivery.

Fig. 2 |

Hydrogels provide a unique strategy for local administration of RNA, overcoming some of the difficulties associated with systemic RNA delivery. They enable a localized, controlled and sustained delivery of high levels of payloads, while maintaining RNA biological activity. Off-target effects and the need for multiple payload administrations in systemic delivery may thus be avoided.