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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Mater. 2023 Mar 20;22(7):818–831. doi: 10.1038/s41563-023-01472-w

Fig. 3 |. Functional hydrogels for RNA loading and delivery.

Fig. 3 |

a, RNA is loaded into hydrogel either with no manipulation (naked RNA) or by means of nanocarriers. b, RNA-loaded hydrogels can be used as implantable scaffolds or as injectable gels for local RNA delivery. The fine-tunable physical, biochemical and biological features of hydrogels allow the sustained and/or controllable release of RNA. Upon cellular entry (for example, via naked RNA or RNA-loaded nanocarriers), RNA reaches the proper subcellular compartment to initiate protein production/inhibition.