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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Mater. 2023 Mar 20;22(7):818–831. doi: 10.1038/s41563-023-01472-w

Fig. 5 |. Hydrogel functional properties for controlled RNA delivery.

Fig. 5 |

a, The ultimate release profile of the encapsulated naked RNA and/or RNA nanocarriers is determined by the hydrogel’s physical features and RNA–hydrogel interactions. b, Upon local administration, the release of the encapsulated RNA can be triggered by external or internal stimuli. c, Illustrative release profiles of encapsulated naked RNA and/or RNA nanocarriers. d, Illustrative biodistribution profiles of RNA therapeutics administered in the naked form or in combination with a hydrogel system. e, Illustrative local accumulation profiles of payload at the implantation site in the naked form or in combination with a hydrogel system.