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. Author manuscript; available in PMC: 2024 Jan 7.
Published in final edited form as: Cancer Discov. 2023 Jul 7;13(7):1678–1695. doi: 10.1158/2159-8290.CD-22-1013

Figure 3.

Figure 3.

SRSF1 accelerates KRASG12D-mediated tumorigenesis. A, Scheme of KSC mouse strain (top), HE and MT staining of pancreata from two-month-old KC and KSC mice (n = 5 per group). Scale bars, 50 μm. B, Quantification of the percentage of pancreatic area exhibiting histological signs of ADM and neoplasia from two-month-old KC and KSC mice (n = 5 per group). Unpaired two-tailed t test, ***p <0.001. Error bars represent mean ± SD. C, Classification of highest-grade PanIN lesions present in two-month-old KC and KSC mice (n = 5 per group). D, Scheme of KPSC mouse strain, HE and MT staining of pancreata from one-month-old KPC and KPSC mice (n = 5 per group). Scale bars, 50 μm. E, Kaplan-Meier survival analysis of KPC and KPSC mice (n = 11 per group). The p value was determined by a log-rank Mantel-Cox test.