Table 3:
Resting Hemodynamics
| Controls (n=149) |
HFpEF<65% (n=319) |
HFpEF≥65% (n=302) |
P valuea | |
|---|---|---|---|---|
| Heart rate, beats/min | 70 ± 11 | 70 ± 12 | 70 ± 13 | 0.799 |
| Mean arterial pressure, mmHg | 96 ± 13 | 99 ± 14 | 99 ± 15 | 0.474 |
| Cardiac output, l/min | 5.4 ± 1.5 | 5.3 ± 1.61 | 5.3 ± 1.61 | 0.010 |
| AVO2 diff, ml/dl | 4.3 ± 0.8 | 4.7 ± 1.01 | 4.5 ± 1.02 | 0.001 |
| Central pressures | ||||
| RA pressure, mmHg | 5 ± 3 | 11 ± 51 | 10 ± 51,2 | <0.001 |
| PA systolic pressure, mm Hg | 28 ± 6 | 42 ± 141 | 41 ± 141 | <0.001 |
| PA mean pressure, mmHg | 17 ± 4 | 28 ± 91 | 27 ± 91 | <0.001 |
| PCWP, mmHg | 9 ± 3 | 17 ± 51 | 17 ± 61 | <0.001 |
| Vascular function | ||||
| PVR, dyn·s·cm−5 | 125 ± 57 | 183 ± 1281 | 171 ± 1241 | <0.001 |
| PA compliance, ml/mmHg | 4.5 ± 1.7 | 3.7 ± 1.81 | 3.7 ± 1.81 | <0.001 |
| SVR, dyn·s·cm−5 | 1446 ± 430 | 1452 ± 460 | 1460 ± 502 | 0.271 |
| TAC, ml/mm Hg | 1.2 ± 0.5 | 1.1 ± 0.51 | 1.1 ± 0.51 | 0.001 |
| Ea, mm Hg/ml | 1.8 (1.6, 2.3) | 2.0 (1.6, 2.4)1 | 2.0 (1.5, 2.6)1 | 0.001 |
| LV EDPVR | ||||
| V15, ml | 110 (96, 131) | 113 (94, 134) | 102 (90, 121)1,2 | 0.001 |
| V15/BSA, ml/m2 | 57 (49, 65) | 53 (46, 62)1 | 50 (44, 57)1,2 | <0.001 |
| V30, ml | 124 (108, 146) | 128 (106, 150) | 115 (101, 136)1,2 | 0.001 |
| V30/BSA, ml/m2 | 64 (55, 73) | 60 (52, 69)1 | 56 (49, 64)1,2 | <0.001 |
| LV stiffness β | 5.90 (5.86, 5.95) | 6.08 (5.93, 6.52)1 | 6.15 (5.95, 6.52)1,2 | <0.001 |
| LV systolic function | ||||
| PRSW, mmHg | 94 (77, 117) | 89 (65, 115)1 | 89 (69, 114)1 | <0.001 |
| LVSW/EDV (g/ml) | 0.85 (0.69, 1.07) | 0.70 (0.54, 0.95)1 | 0.70 (0.59, 0.99)1 | <0.001 |
AVO2 diff = arterial-venous oxygen content difference; BSA=body surface area; Ea=systemic effective arterial elastance; EDV=LV end diastolic volume; LVSW=left ventricular stroke work; PA=pulmonary artery; PCWP=pulmonary capillary wedge pressure; PRSW=pre-load recruitable stroke work; PVR=pulmonary vascular resistance; RA=right atrial; SVR=systemic vascular resistance; TAC=total arterial compliance; V15=LVEDV at a common LV end-diastolic pressure of 15 mmHg; V30=LVEDV at a common LV end-diastolic pressure of 30 mmHg. Values are expressed as mean ± SD or median (IQR). Final column shows the p value by analysis of variance for any difference between groups.
Significant individual group differences (corrected for multiple hypothesis testing) are then shown by superscripts 1 (p<0.05 vs. Controls)
(p<0.05 vs. HFpEF<65%).
Adjusted for sex and BMI, except V15/BSA and V15/BSA, which are only adjusted for sex