Table 1:

Previous cases from brain tumors with NUTM1 fusions

Reference	Age/Sex	Site	Histology	IHC positive	Treatment/Outcome	Fusion
Dickson et al [21]	3 yo male	Left Parietal	Small round cells. Epithelioid-polygonal cells with a reticular-alveolar pattern and prominent myxoid stroma. Nuclear molding, speckled chromatin and conspicuous mitotic activity.	GFAP (2+, focal), synaptophysin (1+), NUT (5+).	Surgery, Chemo, DOD (12 mo)	BRD4:: NUTM1
Sturm et al [24]	3 yo female	Temporal/Parietal	Small-cell phenotype, alveolar and fascicular growth	NUT (strong)	Unknown AWD (273 mo)	CIC:: NUTM1
Sturm et al [24]	2 yo female	Frontal/Parietal	Small-cell phenotype, alveolar and fascicular growth	NUT (strong)	Unknown	CIC:: NUTM1
Siegfried et al [23]	21 yo female	Frontal	Fascicular architecture and chondro-myxoid areas; some neuron-like tumor cells; large nucleoli	NUT, GFAP (strong), p53, CD56.	Surgery, NED (16 mo)	ATXN1::NUTM1
Ko et al [22]	29 yo female	Right Frontal/Temporal	Variegated tumor consisting mostly of small epithelioid cells with myxoid or fibrillar background	NUT, CD99, CD56, p53, GFAP (focal), neurofilament (focal).	Surgery, Chemo, DOD (1 mo)	PARD3B:: NUTM1
This case	1.5 yo male	Right Temporal/Parietal	Embryonal cell types, as well as epithelioid or rhabdoid-like cell types	GFAP (focal), Ki-67 high, NUT (strong), p53 wildtype	Surgery, Chemo, DOT (5 mo)	ZNF532::NUTM1

GFAP=glial fibrillary acid protein; Chemo=chemotherapy; DOD=died of disease; AWD=alive with disease; NED=no evidence of disease; DOT=died of treatment.