Table 2.

Principal components analysis phenotype clusters significantly associated with EAA (FDR q-value <0.1)

Factor	Description	Odds ratio (95% CI)	p	q
1	Sit/rise score, mean leg balance, 6-minute walk distance, body mass index (−), waist circumference (−)	0.73 (0.59, 0.89)	0.0025	0.048
2	Pulmonary function tests (forced vital capacity, carbon monoxide diffusing capacity [DLCO], forced expiratory volume), grip strength, hemoglobin, hematocrit, red blood cells (absolute), 6-minute walk distance, sex	1.60 (1.18, 2.20)	0.0029	0.048
12	Total cholesterol, low-density lipoprotein	1.32 (1.07, 1.62)	0.0091	0.0997

Odds ratios (ORs) from a logistic regression model adjusted for sex; ORs >1 indicate an increase in EAA with an increase in the factor; ORs <1 indicate a decrease in EAA with an increase in the factor. Components of each factor with absolute loadings <0.4 are shown; variables designated “(−)” are negatively loaded on the factors while all others are positively loaded.

CI, confidence interval; EAA, epigenetic age acceleration; FDR, false discovery rate