TABLE 4.
Mean rates of longitudinal change in global cortical SUVR and Centiloid in the gantenerumab and placebo arms as measured by 11C-PiB and 18F-florbetapir
| Gantenerumab | Placebo | Gantenerumab versus placebo t-value (p-value) | Gantenerumab versus placebo Cohen’s d [95% CI] | |
|---|---|---|---|---|
| Mean annualized global cortical SUVR- 11 C-PiB change (SE) | −0.045 (0.009) | 0.022 (0.008) | −8.9 (6.6×10−12)*** | −2.24 [−2.90, −1.58] |
| Mean annualized global cortical SUVR- 18 F-florbetapir change (SE) | −0.030 (0.008) | 0.015 (0.009) | −6.6 (1.7×10−8)*** | −1.64 [−2.21, −1.06] |
| Global cortical SUVR- 11 C-PiB change versus SUVR- 18 F-florbetapir change t-value (p-value) | −3.9 (0.00034)*** | 1.2 (0.26) | ||
| Global cortical SUVR- 11 C-PiB change versus SUVR- 18 F-florbetapir change Cohen’s d [95% CI] | −0.61 [−0.94, −0.27] | 0.23 [−0.17, 0.63] | ||
| Mean annualized global cortical Centiloid- 11 C-PiB change (SE) | −4.6 (0.9) | 2.2 (0.8) | −8.9 (6.6×10−12)*** | −2.24 [−2.90, −1.58] |
| Mean annualized global cortical Centiloid- 18 F-florbetapir change (SE) | −5 (1) | 3 (2) | −6.6 (1.7×10−8)*** | −1.64 [−2.21, −1.06] |
| Global cortical Centiloid- 11 C-PiB change versus Centiloid- 18 F-florbetapir change t-value (p-value) | 0.62 (0.54) | −0.38 (0.71) | ||
| Global cortical Centiloid- 11 C-PiB change versus Centiloid- 18 F-florbetapir change Cohen’s d [95% CI] | 0.10 [−0.21, 0.40] | −0.08 [−0.47, 0.32] |
*
p-value<0.05,
**
p-value<0.01,
***
p-value<0.001.
Abbreviations: CI (confidence interval), SE (standard error).