Table 5.
Summary of lisaftoclax PK parameters following a single oral administration.
| Analyte | Dose (mg) |
Subject Number |
T1/2 (h) |
Tmax (h) |
Cmax (μg/mL) |
AUC0-24 (h*μg/mL) |
|---|---|---|---|---|---|---|
| Lisaftoclax (APG-2575) | 50 | 1 | 2.84 | 3 | 0.0391 | 0.261 |
| 100 | 1 | 3.85 | 6 | 0.229 | 1.80 | |
| 200 | 2 | 3.84 ± 0.16 | 4 (4~4) | 0.294 ± 0.004 | 2.41 ± 0.37 | |
| 400 | 8 | 4.43 ± 0.57 | 6 (4~8) | 0.822 ± 0.334 | 6.85 ± 2.91 | |
| 600 | 7 | 4.68 ± 1.03 | 6 (4~8) | 0.761 ± 0.298 | 7.81 ± 2.84 | |
| 800 | 7 | 4.34 ± 0.53 | 4 (4~6) | 0.982 ± 0.384 | 7.25 ± 2.24 | |
| 1,000 | 6 | 6.10 ± 1.52 | 8 (6~8) | 1.69 ± 1.22 | 18.3 ± 13.1 | |
| 1,200 | 6 | 4.86 ± 1.01 | 6 (3~8) | 1.20 ± 0.48 | 12.3 ± 4.82 |
Data was represented as Mean ± SD; Tmax was represented as Median (range).